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From Oman to Rome: the evolving landscape of US-Iran talks

The second round of nuclear talks between the United States and Iran is set to take place in Italy, following a successful first round in Oman. The choice of Rome signals an effort to elevate the diplomatic profile of the discussions

Decoding the news. As Axios has revealed, a second round of nuclear talks between the US and Iran is set for Saturday in Rome, Italy.

  • After a successful first round in Oman, the US is pushing to keep the format direct — with officials from both sides in the same room.
  • The US suggested the Italian capital as the new venue, signalling a move to raise the diplomatic profile of the talks.
    • Omani mediators will still be present, but Washington wants the shift from indirect to direct talks to become permanent.

Watch JD Vance. The US vice president, JD Vance, will be in Rome simultaneously.

  • While there’s no confirmation of his involvement, any participation—even symbolic—would elevate the talks significantly and signal the White House’s direct investment in the process.

What we’re watching. On April 17-18, Italian Prime Minister Giorgia Meloni will be in Washington for a meeting with President Donald Trump and his administration.

  • The discussions also touch upon the ongoing U.S.-Iran nuclear talks in Rome. Previously, negotiations over Iran’s nuclear program were under the JCPOA format, led by the E3 (UK, France, Germany).
  • Trump has never favoured that agreement, and we may now see a different approach that could also involve Italy.

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